| 168 | 5 | 22 |
| 下载次数 | 被引频次 | 阅读次数 |
布鲁菌是一种缺乏典型毒力因子的胞内寄生菌,可以抵御宿主细胞内酸性、缺氧、强氧化性以及营养匮乏等多种不利环境,是形成布鲁菌致病力的重要原因。布鲁菌的二元调控系统可以对这些环境信号进行感应、传递并做出相应的适应。论文对布鲁菌二元调控系统的研究现状及二元调控系统在布鲁菌病防控中的应用进行了系统的介绍。
Abstract:Brucellais a pathogen without classic virulence genes.The pathogenicity of Brucellais due to its ability to adapt to the intracellular environment including low levels of nutrients and oxygen,acidic pH and reactive oxygen intermediates.Two component systems are designed to sense diverse stimuli,transfer signals and enact an appropriate adaptive physiological response.This paper reviewed the developments in Brucellatwo component systems.
[1]郝艳华,张维,陈明.细菌双组分系统的研究进展[J].中国农业科技导报,2012,14(2):67-72.
[2]贲百灵,孙广力,娄永利.布鲁氏菌病流行现状和防治建议[J].畜牧兽医科技信息,2005(7):38-39.
[3]Kohler S,Foulongne V,Ouahrani-Bettache S,et al.The analy-sis of the intramacrophagic virulome of Brucella suis deciphersthe environment encountered by the pathogen inside the macro-phage host cell[J].Proc Natl Acad Sci USA,2002,99(24):15711-15716.
[4]DelVecchio V G,Kapatral V,Redkar R J,et al.The genome se-quence of the facultative intracellular pathogen Brucellamelitensis[J].Proc Natl Acad Sci USA,2002,99(1):443-448.
[5]Sola-Landa A,Pizarro-Cerda J,Grillo M J,et al.A two-compo-nent regulatory system playing a critical role in plant pathogensendosymbionts is present in Brucella abortus and controls cellinvasion and virulence[J].Mol Microbiol,1998,9(1):125-138.
[6]Guzman-Verri C,Manterola L,Sola-Landa A,et al.The two-component system BvrR/BvrS essential for Brucella abortusvirulence regulates the expression of outer membrane proteinswith counterparts in members of the Rhizobiaceae[J].ProcNatl Acad Sci USA,2002,99(19):12375-12380.
[7]Manterola L,Moriyón I,Moreno E,et al.The lipopolysaccha-ride of Brucella abortus BvrS/BvrR mutants contains lipid Amodifications and has higher affinity for bactericidal cationicpeptides[J].J Bacteriol,2005,187(16):5631-5639.
[8]Manterola L,Guzman-Verri C,Chaves-Olarte E,et al.BvrR/BvrS-controlled outer membrane proteins Omp3aand Omp3bare not essential for Brucella abortus virulence[J].Infect Im-mun,2007,75(10):4867-4874.
[9]Viadas C,Rodriguez M C,Sangari F J,et al.Transcriptome a-nalysis of the Brucella abortus BvrR/BvrS two-component reg-ulatory system[J].PLoS One,2010,5(4):e10216.
[10]Martinez-Nunez C,Altamirano-Silva P,Alvarado-Guillen F,etal.The two-component system BvrR/BvrS regulates the ex-pression of the type IV secretion system VirB in Brucellaabortus[J].J Bacteriol,2010,192(21):5603-5608.
[11]Wu Q,Pei J,Turse C,et al.Mariner mutagenesis of Brucellamelitensis reveals genes with previously uncharacterized rolesin virulence and survival[J].BMC Microbiol,2006,6:102.
[12]Zhang X,Ren J,Li N,et al.Disruption of the BMEI0066geneattenuates the virulence of Brucella melitensis and decreasesits stress tolerance[J].Int J Biol Sci,2009,5(6):570-577.
[13]Liu W,Dong H,Liu W,et al.OtpR regulated the growth,cellmorphology of B.melitensis and tolerance toβ-lactam agents[J].Vet Microbiol,2012,159(1-2):90-98.
[14]Swartz T E,Tseng T S,Frederickson M A,et al.Blue-light-activated histidine kinases:two-component sensors in bacteria[J].Science,2007,317(5841):1090-1093.
[15]Foulongne V,Bourg G,Cazevieille C,et al.Identification ofBrucella suis genes affecting intracellular survival in an invitro human macrophage infection model by signature taggedtransposon mutagenesis[J].Infect Immun,2000,68(3):1297-1303.
[16]Ishida M L,Assumpcao M C,Machado H B,et al.Identifica-tion and characterization of the two-component NtrY/NtrXregulatory system in Azospirillum brasilense[J].Braz J MedBiol Res,2002,35(6):651-661.
[17]Gregor J,Zeller T,Balzer A,et al.Bacterial regulatory net-works include direct contact of response regulator proteins:interaction of RegA and NtrX in Rhodobacter capsulatus[J].JMol Microbiol Biotechnol,2007,13(1-3):126-139.
[18]Pawlowski K,Klosse U,de Bruijn F J.Characterization of anovel Azorhizobium caulinodans ORS571two-component reg-ulatory system,NtrY/NtrX,involved in nitrogen fixation andmetabolism[J].Mol Gen Genet,1991,231(1):124-138.
[19]Carrica M C,Fernandez I,Marti M,et al.The NtrY/X two-component system of Brucellaspp.acts as a redox sensor andregulates the expression of nitrogen respiration enzymes[J].Mol Microbiol,2012,85(1):39-50.
[20]Dorrell N,Spencer S,Foulonge V,et al.Identification,cloningand initial characterisation of FeuPQ in Brucella suis:a newsub-family of two-component regulatory systems[J].FEMSMicrobiol Lett,1998,162(1):143-150.
[21]Lestrate P,Dricot A,Delrue R M,et al.Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identifiedduring the acute phase of infection in mice[J].Infect Immun,2003,71(12):7053-7060.
[22]Dorrell N,Guigue-Talet P,Spencer S,et al.Investigation intothe role of the response regulator NtrC in the metabolism andvirulence of Brucella suis[J].Microb Pathog,1999,27(1):1-11.
[23]Mirabella A,Yanez Villanueva R M,Delrue R M,et al.Thetwo-component system PrlS/PrlR of Brucella melitensis is re-quired for persistence in mice and appears to respond to ionicstrength[J].Microbiology,2012,158(Pt10):2642-2651.
[24]Utsumi R,Igarashi M.Two-component signal transduction asattractive drug targets in pathogenic bacteria[J].YakugakuZasshi,2012,132(1):51-58.
[25]Santos E V,Silva G,Cardozo G P,et al.In silico characteriza-tion of three two-component systems of Ehrlichia canis and e-valuation of a natural plant-derived inhibitor[J].Genet MolRes,2012,11(4):3576-3584.
[26]Zhou P,Long Q,Zhou Y,et al.Mycobacterium tuberculosistwo-component systems and implications in novel vaccines anddrugs[J].Crit Rev Eukaryot Gene Expr,2012,22(1):37-52.
[27]Grillo M J,Manterola L,deMiguel M J,et al.Increases of effi-cacy as vaccine against Brucella abortus infection in mice bysimultaneous inoculation with avirulent smooth bvrS/bvrRand rough wbkA mutants[J].Vaccine,2006,15(24):2910-2916.
基本信息:
DOI:10.16437/j.cnki.1007-5038.2013.08.006
中图分类号:S852.614
引用信息:
[1]董浩,吴清民.布鲁菌二元调控系统研究进展[J].动物医学进展,2013,34(08):80-83.DOI:10.16437/j.cnki.1007-5038.2013.08.006.
2013-08-20
2013-08-20